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However, clinical trials have shown that both semaglutide (Wegovy, Ozempic) and tirzepatide (Mounjaro) can lead to significant weight loss when combined with a healthy diet and exercise plan

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In contrast, ATF4 mainly drives CHAC1 transcription under stress conditions through its interaction with both the ATF/CRE and ACM motif (Nomura et al., 2020)